Molekularna onkologija - znanja temeljena na novim tehnologijama

Course

Molekularna onkologija - znanja temeljena na novim tehnologijama

ECTS

3.0

Status

Optional course

Execution of classes

P10/S4/V3

Course performers

dr. sc. Koraljka Gall-Trošelj, Voditelj predmeta
dr. sc. Renata Novak-Kujundžić, Nastavnik

Studies on which it's performed

BIOMEDICINA I ZDRAVSTVO

Competencies and learning outcomes

Gaining understanding (advantages, disadvantages, limits) of molecular methods/techniques implemented in the field of molecular oncology during 2010 -2015.


Contents

Cancer genetics and epigenetics; DNA methylation; genomic imprinting and multilevel roles of the CTCF protein; promoter polymorphism in relation to gene activity; histone modifications; chromatine immunoprecipitation; malignant cell transcriptome and application of the –omics methods in molecular oncology;  micro-RNA and their modeling; tools for searching the Gene Bank and other databases; cellular metabolism and carcinogenesis; seminars: analyses of research articles dealing with aspects of oncology (clinical and molecular) relevant for students. Written exam – test.


Literature

  • Montezuma D, Henrique RM, Jeronimo C. Crit Rev Oncog 2015;20(1-2):19-34.

  • Vahid F, Zand H, Nosrat-Mirshekarlou E, Najafi R, Hekmatdoost A.

  • McGuire A, Brown JA, Kerin MJ. Cancer Metastasis Rev 2015;34(1):145-55.

  • Hamm CA, Costa FF. Pharmacol Ther 2015; doi: 10.1016/j.pharmthera.2015.03.003. 

  • Ma X, Wang YW, Zhang MQ, Gazdar AF. Epigenomics 2013;5(3):301-16.

  • Yang Y, Dong X, Xie B, Ding N, Chen J, Li Y, Zhang Q, Qu H, Fang X. Genomics Proteomics Bioinformatics 2015;13(1):46-50.

  • Ong CT, Corces VG. Nat Rev Genet 2014;15(4):234-46.

  • Augoff K, Hryniewicz-Jankowska A, Tabola R. Cancer Lett 2015;358(1):1-7.

  • Cooks T, Harris CC, Oren M. Carcinogenesis 2014;35(8):1680-90.

  • Joosse SA, Gorges TM, Pantel K. EMBO Mol Med 2014;7(1):1-11.


Madhamshettiwar Piyush B, Maetschke SR, Davis MJ, Reverter A, and Ragan MA INsPeCT: INtegrative Platform for Cancer Transcriptomics. Cancer Informatics 2014;13 59-66.


Teaching forms

Lectures (10); seminars (4); practical work (3)


Examination procedure

Written exam - test .