Dissemination activities
Project has been publicized in the official Zagreb Medical School’s journal and presented to the Croatian AD-Patient Association, family members and caregivers via oral and poster presentations. The results achieved in the project have already been and will continue to be widely presented on a large number of national and international conferences targeting AD- and pharmacology oriented scientific community, as well as pharmaceutical industry. In addition to 2 already published review articles most closely related to the topic of the UKF project, results on cytopathological, cognitive and cholinergic characterization are in preparation for publication in the respectable journals and for dissemination by 1 PhD Thesis at UZSM.
Congress Abstracts (results):
1. Šalković-Petrišić M, Knezović A, Riederer P. Streptozotocin-induced experimental model of sporadic Alzheimr’s disease as a tool for testing novel therapeutic approaches in this disease. Neurologia Croatica; 6th Croatian Congress on Alzheimer’s Disease, Primošten, Croatia, October 10-13, 2012
2. Knezović A, Osmanović-Barilar J, Mandel S, Youdim M, Riederer P, Šalković-Petrišić M. Therapeutic effects of multifunctional iron-chelating agent in a streptozotocin-induced rat model of sporadic Alzheimer’s disease. Neurologia Croatica; 6th Croatian Congress on Alzheimer’s Disease, Primošten, Croatia, October 10-13, 2012
3. Knezović A, Knapić M, Šimić G, Šalković-Petrišić M. The expression of glial fibrillary acidic protein in the brain of streptozotocin rat model of sporadic Alzheimer’s disease. Clinical neuropathology; 31/4; 10th European Congress of Neuropathology organized by the British Neuropahological Society in conjuction with Euro-CNS, Edinburgh, Scotland, June 06-09, 2012
4. Knapić M, Knezović A, Šimić G, Šalković-Petrišić M. Hippocampal and cortical neuronal damage in the streptozotocin rat model of sporadic Alzheimer’s disease. Clinical neuropathology; 31/4; 10th European Congress of Neuropathology organized by the British Neuropahological Society in conjuction with Euro-CNS, Edinburgh, Scotland, June 06-09, 2012
5. Šalković-Petrišić M, Knezović A, Knapić M, Šimić G. Amyloid-beta pathology in the brain of a streptozotocin rat model of sporadic Alzheimer’s disease. Clinical neuropathology; 31/4; 10th European Congress of Neuropathology organized by the British Neuropahological Society in conjuction with Euro-CNS, Edinburgh, Scotland, June 06-09, 2012
6. Knezović A, Šalković-Petrišić M. Alteration of memory functions and cholinergic transmission in the brain of the streptozotocin-induced rat model of sporadic Alzheimer’s disease. Book of abstracts, PhD Day of the School of Medicine University of Zagreb, Zagreb, Croatia, May 25, 2012
7. Šalković-Petrišić M, Knezović A, Knapić M, Mandel S, Youdim M, Riederer P. Neuroprotective-neurorestorative potential of the novel multi-target, iron-chelator, M-30 in non-trangenic rat model of sporadic Alzheimer’s disease. Book of abstracts, 12th International Stockholm/Spriengfield Symposium on Advances in Alzheimer Therapy, May 9-12, 2012
8. Knezović A, Knapić M, Mandel S, Moussa Y, Riederer P, Šalković-Petrišić M. Streptozotocin model of sporadic Alzheimer’s disease in rats: characterization and novel drug testing. Book of abstracts, FENS-IBRO School: Drugs and the brain: an Update in Psycho-pharmacology from experimental to clinic, Brag, Portugal, April 15-20, 2012
9. Knezović A, Kuljis RO, Šalković-Petrišić M. Alterations of cholinergic transmission and memory functions in the non-trangenic model of sporadic Alzheimer’s disease. Book of abstracts, SiNAPSA Neuroscience Conference: Central European FENS Regional Meeting, Ljubljana, Slovenia, September 25-29, 2011
10. Knezović A, Osmanović-Barilar J, Grünblatt E, Riederer P, Šalković-Petrišić M. Fol-degrading enzyme expression in a rat model of sporadic Alzheimer’s disease. 10th ISN Advanced School of Neurochemistry: Molecular basis on higher cognitive functions. Delphi, Greece, August 24-28, 2011
11. Knezović A, Osmanović-Barilar J, Riederer P, Kuljis RO, Šalković-Petrišić M. Metabolic response to central streptozotocin application in a rat model of sporadic Alzheimer’s disease. FENS/IBRO Partially Supported School: Metabolic aspects of chronic brain diseases. Reisensburg/Günzburg, Germany, July 20-26, 2011
12. Kuljis RO. The Fourth Element Hypothesis of Alzheimer’s disease pathogenesis. Alzheimer’s and Dementia. 2011; Alzheimer’s Association International Conference on Alzheimer’s Disease (AAICAD). Paris, France, July 16-21, 2011 (CD version)
13. Knezović A, Šalković-Petrišić M. Early changes of cholinergic receptors in hippocampus and parietotemporal cortex of the rat model of sporadic Alzheimer’s disease. Alzheimer’s and Dementia. 2011; Alzheimer’s Association International Conference on Alzheimer’s Disease (AAICAD). Paris, France, July 16-21, 2011 (CD version)
14. Šalković-Petrišić M, Knezović A, Grünblatt E, Brueckner MK, Arendt T, Hoyer S, Riederer P. Correlation of cognitive deficits and brain cholinesterase activity in streptozotocin-intracerebroventricularly treated rat model of sporadic Alzheimer’s disease. Alzheimer’s and Dementia. 2011; Alzheimer’s Association International Conference on Alzheimer’s Disease (AAICAD). Paris, France, July 16-21, 2011 (CD version)
15. Knezović A, Kuljis RO, Riederer P, Šalković-Petrišić M. Non-trangenic rat model of sporadic Alzheimer’s disease: Is it suitable for testing of novel drug therapies?. Book of abstracts, 7th Young Scientist Association PhD Symposium, Wien, Austria, June 15-16, 2011
16. Knezovć A, Marjanović A,Osmanović-Barilar J, Bradamante V, Riederer P, Šalković-Petrišić M. Early changes of acetylcholnesterase activity and insulin system in the brain of the streptozotocin-intracerebroventricularly treated rat model of sporadic Alzheimer’s disease. Neurodegenerative diseases. 2011; 10th International Conference on Alzheimer’s & Parkinson’s diseases. Barcelona, Spain, March 09-13, 2011 (CD version)
17. Šalković-Petrišić M, Knezović A,Osmanović-Barilar J, Grünblatt E, Riederer P. Correlation of cognitive deficits and cerebral amyloid angiopathy development in the streptozotocin-rat model of sporadic Alzheimer’s disease. Neurodegenerative diseases. 2011; 10th International Conference on Alzheimer’s & Parkinson’s diseases. Barcelona, Spain, March 09-13, 2011 (CD version)
Publications:
1. Knezović A, Osmanović Barilar J, Ćurlin M, Hof PR, Šimić G, Riederer P, Šalković-Petrišić M. Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer’s disease. J Neural Transm 2015; 122(4): 577-592.
2. Šalković-Petrišić M, Knezović A, Hoyer S, Riederer P. What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer’s disease, about the therapeutic strategies in Alzheimer’s research. J Neural Transm 2013; 120(1): 233-252
3. Kuljiš RO, Šalković-Petrišić M. Dementia, diabetes, Alzheimer’s disease and insulin resistance in the brain: Progress, dilemmas and new opportunities to tackle intersecting epidemic. J Alzheimers dis. 2011; 25 (1): 29-41.
Project announcement to the scientific community and the Alzheimer’s disease patients and caregivers:
1. Šalković-Petrišić M, Knezović A, Šimić G. Novosti u temeljnim istraživanjima Alzheimerove bolesti: karakterizacija štakorskog modela za testiranje novih lijekova. Brain Awareness week, Zageb, Croatia, March 16th 2012
2. Šalković-Petrišić M, Kuljiš R. Cytopahological characterization of the brain in a rat model of sporadic Alzheimer’s disease. Neurologia Croatica 2010; 59 (Suppl. 2): 19-19.
3. Šalković-Petrišić M, Kuljiš R. A new platform for characterization of the rat model of sporadic Alzheimer’s disease Periodicum Biologorum2010; 112 (Suppl. 1): 44-44.
4. Šalković-Petrišić M. Osobno iskustvo i pogled na translacijska istraživanja (engl. Personal experience and view on translational research). mef.hr 2010; 1: 39-40.
Co-applicants publications which acknowledge UKF project 64/10:
1. Foster PP, Rosenblatt KP, Kuljiš RO. Exercise-induced cognitive plasticity, implications for mild cognitive impairment and Alzheimer’s disease. Front Neurol. 2011; 2: 28.
2. Kuljiš RO. The Fourth Element Targeting hypothesis of Alzheimer’s disease pathogenesis and pathophysiology. Front Neurol. 2010; 1: 144.
3. Kuljiš RO. Integrative understanding of emergent brain properties, Quantum Brain hypothesis and Connectome alterations are key challenges to conquer Alzheimer’s. Front Neurol.2010 Aug 26; 1: 15.
Invited lectures:
1. Knezović A. Cognitive deficits and cholinergic neurotransmission in a rat model of sporadic Alzheimer’s disease. Annual meeting of the Croatian Pharmacological Society. Zagreb, Croatia, November 16, 2012.
2. Šalković-Petrišić M. Personal experience and view of the translational research. Medical Information Conference Croatia (MICC), Zagreb, Croatia, June 15, 2012.
3. Šalković-Petrišić M. What do cognitive deficits correlate with in a rat model of sporadic Alzheimer’s disease? „Interdisciplinary Neuroscience”. Symposium in honour of Professor Peter Riederer. Wuerzburg, Germany, April 27-28, 2012.
4. Šalković-Petrišić M. Modelling of sporadic Alzheimer’s disease. 1st WG4 Scientific Meeting: Monoamines and Drugs: New Insights into the Brain Disorders (part of COST Action CM1103 „Structure-based drug design for diagnosis and treatment of neurological diseases”). Zagreb, Croatia, April 26, 2012.
5. Kuljiš R. Panel participation 5th Annual Bazalides Research Symposium, Alzheimer’s Associatian, Houston & Southeast Texas Chapter, Houston, Texas, USA, October 13, 2012.
6. Kuljiš R. Dementia and diabetes: Biological mechanisms underlying the converging worldwide epidemics of diabetes mellitus and Alzheimer’s disease. Mitchell Center for Neurodegenerative Diseases Seminar Series, The University of Texas Medical Branch at Galveston. Galvestone, Texas, USA, April 8, 2011.
Graduate thesis:
1. Dalia Vađunec “Promjene inzulinskog signalnog puta u olfaktornom bulbusu eksperminetalnog štakorskog modela sporadične Alzheimerove bolesti”
Awards:
Award for the best poster:
Knezović A, Osmanović-Barilar J, Mandel S, Youdim M, Riederer P, Šalković-Petrišić M. Therapeutic effects o multifunctional iron-chelating agent in streptozotocin-induced rat model of sporadic Alzheimer’s disease. 6th Croatian Congress on Alzheimer’s disease, Primošten, Croatia, October 10-13, 2012.