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Projekt HRZZ: BrainECM

Hrvatska zaklada za znanost / Croatian Science Foundation

Istraživački projekt / Research Project IP-2019-04-3182

Trajanje projekta / Project duration: 1. 3. 2020 - 1. 3. 2024

Naslov / Title: MOŽDANI IZVANSTANIČNI MATRIKS U RAZVITKU I PERINATALNOJ HIPOKSIJI / BRAIN EXTRACELLULAR MATRIX IN DEVELOPMENT AND PERINATAL HYPOXIA (BRAINECM)

Voditelj / Principal Investigator: Professor Nataša Jovanov Milošević

Istraživači / Researchers:

  • Banovac, Ivan - MD, PhD
  • Bobić-Rasonja, Mihaela - MD, PhD
  • Darmopil, Sanja - Asistant professor, PhD
  • Di Donato, Nataliya - MD, Medical Geneticist
  • Drlje Matea, MD
  • Milković-Periša, Marija - Assistant professor, MD, Pathology Specialist
  • Hranilović, Dubravka - Full Professor, PhD
  • Knezović, Vinka - MD, PhDž
  • Nikolić, Barbara - mag. exp. biol., PhD Student
  • Petanjek, Zdravko - Full Professor, MD, PhD
  • Pogledić, Ivana - MD, Radiology Specialist, PhD
  • Petrović, Davor - MD, Pathology Specialist
  • Radošević, Velena - MD, Obstetrics & Gynaecology Specialist
  • Sitaš, Barbara - MD, Neurology Specialist, PhD student
  • Trnski, Sara -  DVM, PhD

Sažetak

Unatoč dostignućima u razumijevanju važnosti moždanog izvanstaničnog matriksa (ECM, difuznog ili kondenziranog kao perineuronske mreže, PNN) za fiziološke i patološke procese u mozgu, on je još uvijek daleko manje prepoznat i istražen od staničnih elemenata. U cilju novih spoznaja o ključnim molekulama i razvojnim događajima u ECM-u, posebno onih koji su izraženi u ljudskom mozgu, istraživači sa HIIM-a u  Zagrebu i Tehničkog Sveučilišta u Dresdenu, s kliničarima-istraživačima s KBC Zagreb i AKH Sveučilišta u Beču će ujediniti znanstvene pristupe, modele (ljudski, štakorski i organoidi) i metodologije (histološke, molekularne, bihevioralne i magnetska rezonancija (MR) 3T i 7T) kako bi se odgovorilo na sljedeće znanstvene izazove: (1) otkriti značajne razlike u sastavnicama ECM-a između fetalnih zona, odjeljaka, aksonskih (strata) i kortikalnih (layers) slojeva; (2) otkriti vremensko-prostorne obrasce ekspresije molekula ECM-a telencefaličke stijenke i bazalnih ganglija u razvitku i definirati ključne vremenske točke ireverzibilnih promjena ekspresijskih obrasca prijelazom u zreli oblik ECM-a; (3) otkriti korelate fetalnih ECM obrazaca na slikovnim prikazima MR u zdravlju (čovjek i štakor) i nakon blage do umjerene perinatalne hipoksije (štakor); (4) otkriti molekularni fenotip, staničnu i prostorno-vremensku distribuciju PNN u razvitku (čovjek i štakor) i promjene istih nakon perinatalne hipoksije u štakora te (5) korelirati ove promjene s bihevioralnim posljedicama hipoksije. Očekujemo da će istraživanje omogućiti da procijenimo značaj i ulogu molekula, obrazaca i reorganizacijskih procesa moždanog ECM-a. Rezultati projekta bit će nove znanstvene spoznaje, publikacije, unapređenje edukacije i pozicioniranje za daljnje međunarodne projekte usmjerene na razvoj novih istraživačkih, dijagnostičkih i terapijskih strategija za neurorazvojne poremećaje kao što su kognitivni deficiti, epilepsija, autizam ili shizofrenija.

Abstract

Despite recent advances in the understanding of the importance of the neural extracellular matrix (ECM,  diffused or condensed as perineuronal nets, PNN) for physiological and pathological processes in the brain, it is still widely less recognized and researched than different neural cellular elements. To combat the lack of knowledge on key ECM players relevant for human brain development, basic researchers (at CIBR, Zagreb, and TU, Dresden) and clinically oriented researchers (at CHC Zagreb, AKH Vienna) will unite scientific approaches, models (human, rat, and organoids) and methodologies (3T and 7T magnetic resonance imaging (MRI), histological, molecular and behavioral), to address the following scientific aims: (1) to detect major differences in ECM constituents among the fetal brain zones, compartments, axonal strata, and cortical layers; (2) to disclose the different ECM expression patterns in the developing brain and (3) define the crucial time points of ECM expression patterns irreversible up-turns in transition to mature ECM form; (4) to reveal the correlates of the fetal ECM patterns in high-resolution MRI in health (human, rat) and after mild to moderate perinatal hypoxia in rat; (5) to disclose molecular phenotype, neuronal and spatial-temporal distribution of the PNN in health (human and rat) and their charges after perinatal hypoxia in rat and (6) to correlate the changes with behavioral consequences of the hypoxic lesion. These will enable us to evaluate the significance and the role of ECM constituents, and ECM reorganization, for the developmental processes (proliferation, migration, axon growth, folding, and synaptogenesis) in the human brain, in health and disorders. The outcome of the project will be new knowledge, publications, advances in education, and positioning for joint international proposals towards ECM-based research, diagnostic and therapeutic strategies, for neurodevelopmental disorders as cognitive disabilities, epilepsy, autism or schizophrenia

Obranjene doktorske disertacije / Defended doctoral thesis:

Bobić-Rasonja M (2021) Reorganizacijski procesi u fetalnoj prednjoj i srednjoj regiji cingularne vijuge čovjeka / Reorganizational processes in human fetal anterior cingulate and midcingulate region

Trnski S (2022) Promjene perineuronskih mreža u mozgu štakora nakon kontrolirane kratkotrajne perinatalne hipoksije/Changes of perineuronal nets in the rat brain after controlled short-term perinatal hypoxia

Znanstveni radovi / Scientific publications

Parichha A, Suresh V, Chatterjee M,  Kshirsagar A,  Ben-Reuven L,  Olender T, Taketo MM, Radošević V, Bobić-Rasonja M, Trnski S, Holtzman MJ, Jovanov-Milošević N, Reiner O, Tole S.   Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate.  Nature Communications (2041-1723) 13 (2022), 1; 633, 20

Trnski S, Nikolić B, Ilić K, Drlje M, Bobić-Rasonja M, Darmopil S, Petanjek Z, Hranilovic D, Jovanov-Milošević N. The Signature of Moderate Perinatal Hypoxia on Cortical Organization and Behavior: Altered PNN- Parvalbumin Interneuron Connectivity of the Cingulate Circuitries. Frontiers in Cell and Developmental Biology (2296-634X) 10 (2022); 1, 17

Sitaš B, Bobić-Rasonja M, Mrak G, Trnski S, Krbot-Skorić M, Orešković D, Knezović V, Petelin Gadže Ž, Petanjek Z, Šimić G, Kolenc D, Jovanov-Milošević N. Reorganization of the Brain Extracellular Matrix in Hippocampal Sclerosis. (2022) International Journal of Molecular Sciences (1422-0067) 23, 15; 1-19

Banovac I, Sedmak D, Esclapez M, Petanjek Z. The Distinct Characteristics of Somatostatin Neurons in the Human Brain. Molecular neurobiology (2022) (0893-7648) 59, 8; 4953-4965

Pogledic I, Schwartz E, Bobić-Rasonja M, Mitter C, Baltzer P, Gruber GM, Milković-Periša M, Haberler C, Bettelheim D, Kasprian G, Judaš M, Prayer D, Jovanov-Milošević N. 3T MRI signal intensity profiles and thicknesses of transient zones in human fetal brain at mid-gestation. European Journal of Pediatric Neurology (2021) (1090-3798) 35 (2021); 67-73

Banovac I, Sedmak D, Judaš M, Petanjek Z. Von Economo Neurons – Primate-Specific or Commonplace in the Mammalian Brain?, Frontiers in Neural Circuits, 15 (2021), 714611, 17 doi:10.3389/fncir.2021.714611

Bobić-Rasonja M, Pogledić, I, Mitter, C, Štajduhar, A, Milković-Periša, M, Trnski S,Bettelheim, D, Hainfellner, J,Judaš, M, Prayer, D, Jovanov-Milošević, N.Developmental differences between the limbic and neocortical telencephalic wall: an intrasubject slice-matched 3T MRI-histological correlative study in humans, Cer. Cortex, doi: 10.1093/cercor/bhab030, 2021

Parichha A, Suresh V, Chatterjee M, Kshirsagar A, Ben-Reuven L, Olender T, Taketo MM, Radosevic V, Bobic-Rasonja M, Trnski S, Jovanov-Milošević N, Reiner O, Tole S. Canonical Wnt signaling exerts bidirectional control on choroid plexus epithelial development. bioRxiv 2020.12.08.415588; doi: https://doi.org/10.1101/2020.12.08.415588

Milos, Ruxandra-IuliaJovanov-Milosevic, NatasaMitter, Christian; et al. Developmental dynamics of the periventricular parietal crossroads of growing cortical pathways in the fetal brain - In vivo fetal MRI with histological correlation. NEUROIMAGE, 116553; 210; 2020.  ‏ 

Vandervore, Laura V.Schot, RachelMilanese, Chiara; et al.TMX2 Is a Crucial Regulator of Cellular Redox State, and Its Dysfunction Causes Severe Brain Developmental Abnormalities. AMERICAN JOURNAL OF HUMAN GENETICS, 105; 6:1126-1147; 2019. 

Bobić Rasonja M, Orešković D, Knezović V, Pogledić I, Pupačić D, Vukšić M, Brugger P, Prayer D, Petanjek Z, Jovanov Milošević N. The Histological and MRI Study of the Development of the Human Indusium Griseum. CerCortex; DOI: 10.1093/cercor/bhz004 (Epub 2019 Feb 4).

Čuljat M and Jovanov Milošević N. Callosal septa express guidance cues and are paramedian guideposts for human corpus callosum development. JANAT (accepted 2018) DOI:10.1111/joa.13011.

Sedmak G, Jovanov Milošević N, Puskarjov M, Kaila K, Judaš M, Developmental Expression Patterns of KCC2 and Functionally Associated Molecules in the Human Brain. CerCortex.2016 Dec; 26(12) 4574-4589.

Jovanov Milošević N, Judaš M, Aronica E, Kostović I. Neural ECM in the laminar organization and connectivity development in the healthy and diseased human brain. Prog Brain Res.2014; 214:159-78.

Kostović I, Jovanov Milošević N, Radoš M, Sedmak G, Benjak V, Kostović-Srzentić M, Vasung L, Čuljat M, Radoš M, Hüppi P, Judaš M. Perinatal and early postnatal reorganization of the subplate and related cellular compartments in the human cerebral wall as revealed by histological and MRI approaches. Brain Struc Func 2014 Jan;219(1) 231-253.

Petanjek Z, Sedmak D, Dzaja D, Rasin RM, Jovanov Miloševic N. The Protracted Maturation of Associative Layer IIIC Pyramidal Neurons in the Human Prefrontal Cortex During Childhood: A Major Role in Cognitive Development and Selective Alteration in Autism. Front Psychiatry, 10:122.

Ilić K, Mlinac-Jerković K, Jovanov Milošević N, Šimić G, Habek N, Bogdanović N, Kalanj-Bognar S. Hippocampal expression of cell-adhesion glycoprotein neuroplastin is altered in Alzheimer's disease. Journal of cellular and molecular medicine .J Cell Mol Med. 2019 Feb; 23(2):1602-1607.

Herrera-Molina R, Mlinac-Jerković K, Ilić K, Stober F, Vemula SK, Sandoval M, Jovanov Milošević N, Šimić G, Smalla KH, Goldschmidt J, Kalanj-Bognar S, Montaq G. Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: implication for cognitive deterioration. SCIENTIFIC REPORTS: 7 No7273, ( 2017)

Blažević SA, Šoltić D, Nikolić B, Ilić K, Jovanov Milošević N, Hranilović D. Perinatal Exposure of Rats to 5-Hydroxytryptophan Affects Midbrain Serotonin Homeostasis.Journal of Pharmacy and Pharmaceutical Research,2(2018), 1; 2, 8.

Kongresna priopćenja / Conference publications:

  1. Banovac, I., Petanjek, Z. & Sedmak, D. (2021) SOMATOSTATIN NEURONS IN THE HUMAN PREFRONTAL CORTEX. In: Virtual FENS Regional Meeting 2021 - Book of Abstracts.
  2. Banovac, I., Petanjek, Z. & Sedmak, D. (2021) VENTRO-DORSAL DIFFERENCES IN PROPORTIONS OF GABAERGIC INTERNEURON POPULATIONS IN THE HUMAN PREFRONTAL CORTEX. In: 8th Croatian Neuroscience Congress - Book of Abstracts.
  3. Nikolić B, Trnski S, Hranilović D, Jovanov-Milošević N. (2021) INCREASED DOPAMINE SIGNALING IN THALAMUS OF ADOLESCENT RATS NEONATALLY EXPOSED TO MILD NORMOBARIC HYPOXIA. In: 8th Croatian Neuroscience Congress - Book of Abstracts
  4. Sitaš B, Bobić-Rasonja M, Knezović V, Trnski S, Bilić K, Orešković D, Mrak G, Petanjek, Z, Petelin Gadže Ž, Šimić G, Kolenc D, Jovanov-Milošević N. (2021) EXTRACELLULAR MATRIX PROFILE IN HIPPOCAMPAL SCLEROSIS. In: 8th Croatian Neuroscience Congress - Book of Abstracts.
  5. Trnski S, Nikolić B, Ilić K, Drlje M, Bobić-Rasonja M, Darmopil S, Petanjek Z, Hranilović D, Jovanov-Milošević N. (2021) LIFELONG CHANGES AFTER PERINATAL MODERATE HYPOXIA: INCREASED NUMBER OF INTERNEURONS AND PERINEURONAL NETS IN THE CINGULATE CORTEX OF THE ADULT RAT. In: 8th Croatian Neuroscience Congress - Book of Abstracts.
  6. Darmopil S, Bobić-Rasonja M, Milković-Periša M, Radošević V, Jovanov-Milošević N. (2021) TRANSIENT BOUNDARIES AND COMPARTMENTS OF DEVELOPING
  7. HUMAN FETAL STRIATUM: THE ROLE OF LECTICANS AND TENASCINS. In: 12th European Congress of Neuropathology – Book of abstracts.
  8. Sitaš B, Knezović V, Bobić-Rasonja M, Trnski S, Bilić K, Mrak G, Petanjek Z, Petelin-Gadže Ž, Kolenc D, Jovanov-Milošević N.  THE HISTOARCHITECTONIC GLYCOSYLATION PATTERN OF DIFFUSED AND PERINEURONAL CONDENSED EXTRACELLULAR MATRIXIN HIPPOCAMPAL SCLEROSIS. In: 12th European Congress of Neuropathology – Book of abstracts.
  9. Bobić-RasonjaM, Pogledić I, Mitter C, Milković-Periša M, Hailfellner J, Judaš M, PrayerD, Jovanov-Milošević N. The interrelation of developmental zones' thicknesses in mid-fetal human brain: a comparative MRI-histological study. FENS 2020 Virtual Forum, 7/2020.
  10. Bobić-Rasonja M, Sedmak G, Knezović V, Radošević V, Jovanov-Milošević N. Transcriptome analysis of the human fetal anterior cingulate gyrus. Perinatal Origins of Neuropsychiatric Disorders: from molecular mechanisms to therapeutic perspectives. Palermo, Italy, 5/2019. https://www.bib.irb.hr/1006369
  11. Bobić-Rasonja M, Štajduhar A, Sedmak G, Petrović D, Jovanov-Milošević N. Analysis of the MEF2C transcription factor expression in developing human cingulate gyrus.  Hrvatski kongres neuroznanosti, Zadar, Croatia, 9/2019. https://www.bib.irb.hr/1071507
  12. Orešković D, Sitaš B, Bobić M, Jovanov Milošević N.  Expression of Perineuronal Nets in the Human Insula during Fetal and Perinatal Development. Controlling neuronal plasticity-developmental disorders and repair. Institute of Experimental Medicine CAS; Vila Lanna, Prague, Czechia; 12/2018.
  13. Bobić M, Radošević V, Macan M, Jovanov Milošević N. ECM expression pattern in the human fetal cingulate gyrus and its relevance in malformations of cortical development. 1st Neuro-MIG Training School (EU Network on Brain Malformations, CA16118): Genomics and Imaging of Malformations of Brain Development, Zagreb, Croatia, 4/2018.
  14. Bobić M, Knezović V, Sedmak G, Macan M, Radoš M, Vukšić M, Jovanov Milošević N. Immunohistochemical study of reorganizational processes in the human fetal cingulate gyrus. FENS Regional Meeting, Pečuh, Hungary, 9/2017.
  15. Bobić M, Knezović V, Sedmak G, Macan M, Radoš M, Vukšić M, Jovanov Milošević N. Histochemical reorganizational processes in the human cingulate gyrus during midgestation. 6th Croatian Neuroscience Congress, Osijek, Croatia, 9/2017.
  16. Trnski, S; Ilić, K; Nikolić, B; Darmopil, S; Petanjek, Z; Hranilović, D; Jovanov Milošević, N.: Lifelong changes in cingulate cortex and learning behavior after moderate perinatal hypoxia in the rat // FENS 2020 Virtual Forum, Glasgow, Škotska, 2020.
  17. Barbara Nikolić, Sara Trnski, Kristina Košić, Dubravka Hranilović, Nataša Jovanov Milošević: Increased rearing and brainstem dopamine levels in a rat model of mild neonatal normobaric hypoxia // FENS 2020 - Virtual Forum, 11-15 July 2020, Virtualni forum (Glasgow, UK), 2020.
  18. Trnski, Sara; Ilić, Katarina; Nikolić, Barbara; Habek, Nikola; Hranilović, Dubravka; Jovanov Milošević, Nataša: Changes of perineuronal nets morphology, hyperactive behavior and cognitive deficits in mild perinatal hypoxic brain lesion in rats; 7th Croatian Neuroscience Congress; Book of abstracts, str. 61-61; Zadar, Hrvatska; rujan, 2019;
  19. Nikolić, Barbara; Trnski, Sara; Kološnjaj, Ivona; Stipan, Monika; Hranilović, Dubravka; Jovanov Milošević, Nataša: Effects of neonatal normobaric hypoxia on rat behavior at young and adult age; 7th Croatian Neuroscience Congress - Book of abstracts, str. 107-107; Zadar, Hrvatska; rujan, 2019.;
  20. Putar, Darija; Zima, David; Trnski, Sara; Bobić Rasonja, Mihaela; Jovanov Milošević, Nataša: The Semaphorin5A developmental expression and functional role in mice telencephalon; 7th Croatian Neuroscience Congress; Book of abstracts, str. 88-88; Zadar, Hrvatska; rujan, 2019.;
  21. Nikolić, Barbara; Trnski, Sara; Krizman, Matea; Jovanov Milošević, Nataša; Hranilović, Dubravka: Consequences of neonatal normobaric hypoxia on rat behaviour; FENS Regional Meeting - Connecting (Brain) Regions; Book of abstracts., str. 558-558; Beograd, Srbija, srpanj, 2019.;
  22. Trnski, Sara; Ilić, Katarina; Nikolić, Barbara; Habek, Nikola; Hranilović, Dubravka; Jovanov Milošević, Nataša: Lifelong changes in perineuronal nets and the learning behavior in rats after mild perinatal hypoxic brain lesion; 7th Conference of the Mediterranean Neuroscience Society; Book of abstracts, str. 261-261; Marrakech, Maroko; lipanj, 2019.;
  23. Trnski, Sara; Ilić, Katarina; Nikolić, Barbara; Habek, Nikola; Hranilović, Dubravka; Jovanov Milošević, Nataša: A non – invasive rat model of perinatal mild hypoxic brain damage; 14th FELASA Congress; Book of abstracts, str. 133-133; Prag, Češka, lipanj, 2019.;
  24. Trnski, Sara; Ilić, Katarina; Nikolić, Barbara; Orešković, Darko; Habek, Nikola; Hranilović, Dubravka; Jovanov - Milošević, Nataša: The perinatal mild hypoxic brain lesion in rats causes changes in perineuronal nets morphology and impaired learning behavior; Controlling Neuronal Plasticity - developmental disorders and repair; Book of abstracts, str. 45-45; Prag, Češka; prosinac, 2018.;
  25. Trnski, Sara; Ilić, Katarina; Nikolić, Barbara; Orešković, Darko; Habek, Nikola; Hranilović, Dubravka; Jovanov Milošević, Nataša: A new non – invasive model of perinatal mild hypoxic brain lesion causes lifelong changes of perineuronal nets and learning behavior in rats; Nikola Škreb Symposium: "New platforms in developmental biology - towards the clinical application", Book of abstracts, str. 37-37; Zagreb, Hrvatska, studeni, 2018.;
  26. Zima, David; Putar, Darija; Trnski, Sara; Bobić Rasonja, Mihaela; Jovanov Milošević, Nataša: The role of Semaphorin5A protein during brain development in rodents; Nikola Škreb Symposium: „New platforms in developmental biology towards the clinical application“; Book of abstracts, str. 38-38; Zagreb, Hrvatska; studeni, 2018.;
  27. Putar, Darija; Zima, David; Trnski, Sara; Bobić Rasonja, Mihaela; Jovanov Milošević, Nataša: In vitro and in situ study of the role of Sema5A in the developing mouse telencephalon; Pokusne životinje u znanstvenim istraživanjima; Book of abstracts, str. 51-52; Zagreb, Hrvatska, listopad, 2018.;
  28. Trnski, Sara; Ilić, Katarina; Nikolić, Barbara; Habek, Nikola; Hranilović, Dubravka; Jovanov Milošević, Nataša: A non-invasive rat model of perinatal hypoxic brain lesion; 3. znanstveno-stručni simpozij Hrvatskog društva za znanost o laboratorijskim životinjama i 2. zajednički skup CroLASA-e i SLAS-a s međunarodnim sudjelovanjem „Pokusne životinje u znanstvenim istraživanjima“; Book of abstracts, str. 47-48; Zagreb, Hrvatska, listopad, 2018.
  29. Drlje M, Trnski S, Štajduhar A, Nikolić B, Bobić-Rasonja M, Hranilović D, Škokić S, Jovanov-Milošević N. In-vivo MRI brain volumetric changes in a rat model of moderate perinatal hypoxia.  // FENS Forum 2022, Abstract E-book, Paris, France, 2022. p. 3427-3427
  30. Trnski S, Ilić K, Bobic-Rasonja M, Banovac I, Drlje M, Darmopil S, Petanjek Z, Jovanov-Milošević N. Moderate perinatal hypoxia causes permanent reorganization of the hippocampal perineuronal nets and interneurons network in rat.  /8th Mediterranean Neuroscience Society (MNS) Conference Abstract Book, 2022. p. 170-171
  31. Banovac I, Bobić-Rasonja M, Trnski S, Petanjek Z, Jovanov Milošević N. SPECIFIC LAMINAR DISTRIBUTION OF PERINEURONAL NETS IN THE HUMAN ANTERIOR CINGULATE CORTEX.  // Neurologia Croatica / Mitrečić, Dinko (ed.). Zagreb: DENONA d.o.o., 2022. p. 42-42.
  32. Bokulić E, Medenica T, Bobić-Rasonja M, Milković-Periša M, Jovanov-Milošević N, Sedmak G. Transcription factors in the developing human subthalamic nucleus.  // E-book of abstracts 8th Croatian Neuroscience Congress, Zagreb: Croatian Society for Neuroscience, 2021. p. 30-30
  33. Nikolić B, Trnski S, Košić K, Hranilović D, Jovanov Milošević, N. Long-term changes of Drd1 and Drd2 gene expression in a rat model of mild neonatal normobaric hypoxia.  // ENCODS 2021 - Book of abstracts Glasgow, UK, 2021. P5A08-P5A08
  34. Sitaš B, Knezović V, Bobić Rasonja M, Trnski S, Bilić K, Mrak G, Petanjek Z, Petelin Gadže Ž, Kolenc D, Jovanov-Milošević N. The histoarchitectonic glycosylation pattern of diffused and perineuronal condensed extracellular matrix in hippocampal sclerosis.  // Clinical neuropathology meeting edition Virtual, 2021. p. 40-41
  35. Hranilović D, Nikolić B, Trnski S, Košić K, Jovanov Milošević N. Altered exploratory behavior and brainstem catecholamine concentrations in rats neonatally exposed to mild normobaric hypoxia.  // 23rd Biennial Meeting of the International Society of Developmental Neuroscience (ISDN2021) Vancouver, Kanada (online), 2021.