
This project is funded by the Croatian Science Foundation.
Newly discovered BMP1 circulating isoforms as biomarkers and therapeutic targets for human diseases
“BMP1-IsoFor”
In this Installation Research Project (IRP) we will further examine the mechanisms of BMP1 isoform function in animal model of chronic kidney disease and liver fibrosis. The primary research area will cover the discovery and establishment of a novel therapeutic target(s) in regenerative medicine. This IRP should also support foundation of a new independent scientific group by Dr. Lovorka Grgurević which will receive an appropriate laboratory space in the Center for Translational and Clinical Research. The entire project team is composed of experts from collaborative institutions and collaborative laboratories.

Figure: Discovery and characterization of Bmp1 gene isoforms in the plasma of healthy individuals and patients with CKD, AMI, LC and pancreatitis. The regions of identified peptides from Bmp1 gene isoforms are indicated by * in (A). Peptide sequence and the Mascot score (MS) are shown in (B). Proteins were identified by liquid chromatography – mass spectrometry (LC-MS) using the Mascot search engine. Peptides with a mass deviation <10 ppm were accepted, and at least two detected peptides were required for protein identification (Grgurevic et al, 2011).
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