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Projekt HRZZ: Novi biomarkeri kronične bolesti presatka protiv primatelja

Povratak

Istraživanje

Naziv projekta Hrvatske zaklade za znanost: Novi biomarkeri kronične bolesti presatka protiv primatelja

Ustanova: Sveučilište u Zagrebu Medicinski fakultet

Voditelj projekta: doc. dr. sc. Dražen Pulanić, dr. med.

Trajanje projekta: 48 mjeseci
Kronična bolest presatka protiv primatelja (eng. chronic Graft-versus-Host disease, cGVHD) je multiorganska aloimuna i autoimuna bolest koja je najvažnija kasna komplikacija nakon alogenične presadbe krvotvornih matičnih stanica (aloPKMS) i vodeći uzrok ne-relapsnog morbiditeta i smrtnosti nakon aloPKMS-a. Zapažena incidencija bolesti kreće se između 30-70% nakon aloPKMS-a i povećava se zbog sve manjeg peritransplantacijskog mortaliteta, starije dobi transplantiranih bolesnika, češće upotrebe perifernih krvotvornih matičnih stanica i sve većeg broja transplantacija od nesrodnog davatelja. Bolest je kompleksna i obično zahvaća više različitih organskih sustava (kožu, oči, usta, jetru, gastrointestinalni sustav, pluća, muskuloskeletni sustav i genitourinarni sistem), a često se prezentira manifestacijama koje nalikuju na promjene u autoimunosnih bolesti. Nužno je pronalaženje prediktivnih i dijagnostičkih biomarkera koji bi koristili u procjeni rizika nastanka, dijagnoze i praćenja, procjene ativnosti i ishoda kroničnog GVHD-a. U Kliničkom bolničkom centru Zagreb 2013. godine osnovan je multidisciplinarni tim stručnjaka za cGVHD po uzoru na onaj formiran na National Institutes of Health (NIH, Bethesda, SAD). Osim što doprinosi poboljšanju skrbi za oboljele od cGVHD-a, ovaj tim omogućuje preciznu interdisciplinarnu kliničku i laboratorijsku evaluaciju bolesti, prikupljanje bioloških uzoraka te nudi veliki potencijal za ispitivanje biomarkera ove teške i potencijalno smrtonosne kasne komplikacije nakon aloPKMS-a.
Cilj ovog novog četverogodišnjeg projekta Hrvatske zaklade za znanost je prospektivnim longitudinalnim istraživanjem ispitati moguće nove biomarkere kroničnog GVHD-a (analizu glikana, faktora koagulacije, laboratorijskih parametara upale, subpopulacije limfocita i monocita) uz detaljno kliničko multidisciplinarno evaluiranje bolesnika korištenjem suvremenih NIH standarda za cGVHD.

Croatian Science Foundation Project title: New biomarkers for chronic graft-versus-host disease

Institution: University of Zagreb School of Medicine

Project leader: Assist. Prof. Dražen Pulanić, MD, PhD

Project duration: 48 months

Chronic graft-versus-host disease (cGVHD) is a multi-organ alloimmune and autoimmune disorder and the most important late complication after allogeneic hematopoietic stem cell transplantation (alloHSCT). It is the major cause of non-relapse morbidity and mortality after alloHSCT. Reported incidence rates of cGVHD range from 30-70% of patients after alloHSCT, and are increasing due to lower peritransplant mortality, older recipients, the more frequent use of peripheral blood graft, and more unrelated donors. It is a complex and multisystem disease, affecting skin, eyes, mouth, liver, gastrointestinal tract, lungs,  muscular-skeletal system, and genital tract, often resembling manifestations of various autoimmune diseases. Predictive and diagnostic biomarkers of cGVHD are much needed to predict its onset, diagnose and monitor the disease, prognoses its course and outcome, and characterize its activity. At the University Hospital Center Zagreb a multidisciplinary team for cGVHD was formed in 2013 according to the team from the National Institutes of Health (NIH, Bethesda, USA).  This approach improved care of patients with cGVHD, but also provides interdisciplinary clinical and laboratory evaluation of this disease, collection of biologic samples with great potential for investigation of biomarkers of this complex and potentially lethal late complication after alloHSTC. The goal of this new 4-year project of the Croatian Science Foundation is to study possible new biomarkers of cGVHD (glycan analysis, coagulation factors, laboratory markers of inflammation, lymphocytes subpopulations, and monocytes) in a prospective longitudinal assessment of cGVHD patients, with their detail multidisciplinary evaluations using modern NIH standards for cGVHD.

PUBLIKACIJE I OSTALEDISEMINACIJSKE AKTIVNOSTI / PUBLICATIONS AND OTHER DISSEMINATION ACTIVITIES

Radovi u CC/SCI časopisima:
Papers published in CC/SCI Journals:

  1. Peric Z, Skegro I, Durakovic N, Desnica L, Pulanic D, Serventi-Seiwerth R, Petricek I, Pavletic SZ, Vrhovac R. Amniotic membrane transplantation-a new approach to crossing the HLA barriers in the treatment of refractory ocular graft-versus-host disease. Bone Marrow Transplant. 2018 Nov;53(11):1466-1469. doi: 10.1038/s41409-018-0140-6.
  2. Ljubas Kelecic D, Lelas A, Karas I, Desnica L, Vukic T, Sabol I, Vranesic Bender D, Serventi Seiwerth R, Peric Z, Durakovic N, Vitali Cepo D, Vrhovac R, Nemet D, Pavletic S, Pulanic D, Krznaric Z. Sarcopenia among patients after allogeneic hematopoietic stem cell transplantation and the impact of chronic graft-versus-host disease. J Cancer Res Clin Oncol. 2020 Nov;146(11):2967-2978. doi: 10.1007/s00432-020-03280-0. Epub 2020 Jun 7.
  3. Crossland RE, Perutelli F, Bogunia-Kubik K, Mooney N, Milutin Gašperov N, Pučić-Baković M, Greinix H, Weber D, Holler E, Pulanić D, Wolff D, Dickinson AM, Inngjerdingen M, Grce M. Potential Novel Biomarkers in Chronic Graft-Versus-Host Disease. Front Immunol. 2020 Dec 23;11:602547. doi: 10.3389/fimmu.2020.602547. eCollection 2020.
  4. Babić A, Kuric L, Zelic Kerep A, Desnica L, Lelas A, Milosevic M, Serventi Seiwerth R, Durakovic N, Peric Z, Mravak Stipetic M, Bilic E, Ceovic R, Baresic M, Vukic T, Ljubas Kelecic D, Mazic S, Bojanic I, Hecimovic A, Bilic E, Zadro R, Vrhovac, Pavletic SZ, Batinic D, Pulanic D. B regulatory cells and monocyte subpopulations in patients with chronic Graft-versus-Host Disease. Croat Med J. 2021;2: (accepted for publication, in press).

Radovi u postupku recenzije u CC/SCI časopisima:
Papers published in CC/SCI Journals:

1) Prenc E, Pulanic D, Pucic-Bakovic M, Ugrina I, Desnica L, Milosevic M, Pirsl F, Mitchell S, Rose J, Vrhovac R, Nemet D, Lauc G, Pavletic SZ. Significant associations of IgG glycan structures with chronic graft-versus-host disease manifestations: results of the cross-sectional NIH cohort study. Front Immunol. (2020; in peer-review)
2) Lelas A, Greinix H, Wolff D, Eissner G, Pavletic SZ, Pulanic D. Von Willebrand Factor, Factor VIII, and other acute phase reactants as biomarkers of inflammation and endothelial dysfunction in chronic Graft-versus-Host Disease. Front Immunol. (2021;in peer-review)

Publikacije u drugim medicinskim časopisima:
Papers published in other medical journals:

  1. Pulanić D, Desnica L, Serventi-Seiwerth R, Mravak-Stipetić M, Bilić E, Čeović R, Duraković N, Perić Z, Kraljević L, Bilić E, Bojanić I, Mazić S, Petriček I, Ljubas D, Vukić T, Klepac Pulanić T, Šepec BI, Barešić M, Karas I, Rajić Lj, Matić T, Dušek D, Grce M, Kurić L, Babić A, Giljević Z, Milošević M, Zadro R, Batinić D, Vrhovac R, Pavletić SZ, Nemet D. Daljnji razvoj multidisciplinarnog tima za kroničnu bolest presatka protiv primatelja KBC Zagreb – novi projekt. Bilten Krohema. 2017;9(1):36-38.
  2. Pulanić D, Desnica L, Serventi-Seiwerth R, Mravak-Stipetić M, Bilić E,  Čeović R, Duraković N, Perić Z, Kraljević L, Bilić E, Bojanić I, Mazić S, Petriček I, Ljubas Kelečić D, Vukić T, Klepac Pulanić T, Šepec BI, Barešić M, Karas I, Rajić Lj, Matić T, Dušek D, Šaban N, Prenc E, Kurić L, Babić A, Ilić I, Rezo Vranješ V, Giljević Z, Milošević M, Pučić Baković M, Grce M, Lauc G, Zadro R, Batinić D, Vrhovac R, Pavletić SZ, Nemet D. Pet godina Multidisciplinarnog tima za kroničnu bolest presatka protiv primatelja KBC Zagreb. Bilten Krohema. 2018;10(1):38-41.
  3. Pulanić D, Desnica L, Perić Z, Samardžić A, Grce M, Vrhovac R, Pavletić SŽ. Zagreb – središte kronične bolesti presatka protiv primatelja početkom studenoga 2018. Bilten Krohema. 2018;10(2):41.
  4. Novi HRZZ projekti na Medicinskom fakultetu. mef.hr 2018;37(1):94.
  5. Poljak Ž. Godišnja nagrada Zaklade KROHEM-a doc. Pulaniću i timu za kronični GVHD za izvrsnost i postignuća u hematologiji. Liječ Novine 2018;172:42-43.
  6. Nagrada KROHEM-a doc. dr. Draženu Pulaniću i timu za kronični GVHD. Medix 2018;132:46.
  7. Pulanić D, Desnica L, Samardžić A, Perić Z, Grce M, Vrhovac R, Pavletić SŽ. Najugledniji eksperti za GvHD i ostale komplikacije nakon transplantacije krvotvornih matičnih stanica u Zagrebu. Bilten Krohema. 2019;11(1):29-31.
  8. Pulanić D, Desnica L, Lelas A, Perić Z, Duraković N, Serventi Seiwerth R, Vrhovac R, Pavletić SŽ. Kronična bolest presatka protiv primatelja – aktivnosti zagrebačkog Multidisciplinarnog tima. Bilten Krohema. 2019;11(2):40.
  9. Pulanić D, Desnica L, Lelas A, Perić Z, Duraković N, Serventi Seiwerth R, Vrhovac R, Pavletić SŽ. Sedam godina Multidisciplinarnog tima za liječenje kronične bolesti presatka protiv primatelja u KBC-u Zagreb. Bilten Krohema. 2020;12(1):58.

Poglavlja u knjigama:
Book chapters:

  1. Dražen Pulanić. Organizacija multidisciplinarnog tima za kroničnu bolest presatka protiv primatelja (cGvHD) u KBC-u Zagreb – primjer dobre prakse. U: Opće zdravlje kroz oralno zdravlje – multidisciplinarni pristup. Marinka Mravak-Stipetić, Jadranka Sertić, Anka Jurišić Kvesić (urednice). Zagreb: Hrvatska komora dentalne medicine. 2019: 226-234. – sveučilišni priručnik.
  2. Mravak Stipetić M, Desnica L, Bojanić I, Pulanić D. Oralna kronična bolest presatka protiv primatelja (cGvHD). U: Opće zdravlje kroz oralno zdravlje – multidisciplinarni pristup. Marinka Mravak-Stipetić, Jadranka Sertić, Anka Jurišić Kvesić (urednice). Zagreb: Hrvatska komora dentalne medicine. 2019: 115-127. – sveučilišni priručnik.


Kongresni sažeci s međunarodnih sastanaka:
Congress abstracts from international meetings:

  1. Peric Z, Skegro I, Durakovic N, Desnica L, Serventi-Seiwerth R, Pulanic D, Petricek I, Pavletic S, Vrhovac R. Severe ocular GVHD successfully treated with amniotic membrane transplantation – case series. ASH poster presentation 2017. Blood 2017;130:3270.
  2. Farhadfar N, Desnica L, Pulanic D, Horn B. Therapy Decisions in Patients Evaluated in Specialized Chronic Graft-Versus-Host (cGVHD) Clinics Using 2014 Consensus Criteria for Diagnosis and Response Assessment. 2018 ASBMT BMT Tandem Meetings poster presentation. Biol Blood Marrow Transplant 2018; 24(3), Supplement: S187.
  3. Babić A, Kurić L, Desnica L, Milošević M, Serventi Seiwerth R, Duraković N, Perić Z, Mravak Stipetić M, Bilić E, Čeović R, Klepac Pulanić T, Petriček I, Vukić T, Šepec IB, Rajić Lj, Bilić E, Šaban N, Barešić M, Ljubas Kelečić D, Mazić S, Bojanić I, Zadro R, Vrhovac R, Pavletic SZ, Batinić D, Pulanić D. Subpopulation of monocytes and B regulatory cells in patient with chronic Graft-versus-Host disease. 23rd Congress of the European Hematology Association. EHA Learning Center. Pulanic D. Jun 16, 2018; 215778. Abstract: PS1492 HemaSphere. 2018;2 (S1): p 1–1113. doi: 10.1097/HS9.0000000000000060
  4. Prenc E, Pulanic D, Ugrina I, Desnica L, Pucic Bakovic M, Stambuk J, Milosevic M, Serventi Seiwerth R, Durakovic N, Peric Z, Vrhovac R, Nemet D, Lauc D, Pavletic SZ. Discriminatory potential of IgG N-glycosylation in chronic graft-versus-disease. The 44th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Poster Sessions. Bone Marrow Transplant. 2018; 1–661.
  5. Ljubas Kelecic D, Desnica L, Vukic T, Vranesic Bender D, Karas I, Barisic A, Domislovic V,  Peric Z, Durakovic N, Serventi Seiwerth R, Vrhovac R, Pulanic D, Nemet D, Pavletic SZ, Krznaric Z. Sarcopenia in cGVHD patients. ESPEN 2018 Abstract. Clinical Nutrition. 2018(September);37(Supplement 1):116.
  6. Pulanic D, Samardzic A, Desnica L, Zadro R, Milošević M, Serventi Seiwerth R, Durakovic N, Peric Z, Coen Herak D, Milos M, Kraljevic L, Mravak Stipetic M, Bilic E, Ceovic R, Klepac Pulanic T, Petricek I, Saban N, Zelic KerepA, Ljubas Kelecic D, Vukic T,  Mazic S, Bojanic I, Bilić E, Batinic D, Vrhovac R, Pavletic SZ. High levels of FVIII and Von Willebrand Factor in chronic Graft-versus-Host Disease patients. The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Poster Sessions. Bone Marrow Transplant 2019;54;144-619. https://doi.org/10.1038/s41409-019-0559-4
  7. Ljubas Kelecic D, Desnica L, Vukic T, Vranesic Bender D, Karas I, Barisic A, Horvat A, Sabol I, Samardzic A, Kraljevic L, Peric Z, Durakovic N, Serventi Seiwerth R, Vrhovac R, Pulanic D, Pavletic SZ, Krznaric Z. Factors affecting nutritional status in chronic GVHD. The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Poster Sessions. Bone Marrow Transplant 2019;54;144-619. https://doi.org/10.1038/s41409-019-0559-4
  8. Desnica L, Hudolin T, Hauptman D, Serventi-Seiwerth R, Durakovic N, Peric Z, Vrhovac R, Pavletic SZ, Pulanic D. Buccal mucosa autograft and other treatment modalities for male genital chronic Graft-versus-Host disease – case series. The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Poster Sessions. Bone Marrow Transplant 2019;54;144-619. https://doi.org/10.1038/s41409-019-0559-4
  9. Jurišić L, Pulanić D, Samardžić A, Sabol A, Družinić V. Croatian experience with the Multdisciplinary team for cGVHD and long term complications after alloHSCT: a nurse`s perspective. The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Nurses Poster Sessions-Information and Education. Bone Marrow Transplant 2019; 54;635-674. https://doi.org/10.1038/s41409-019-0565-6
  10. Belev J, Samardžić A, Rendulić E, Družinić V. Nurse’s role in the Multidisciplinary team for cGVHD and long term complication after HSCT – a case report of a patient with multiple myeloma and multiple sclerosis. The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Nurses Poster Sessions-Information and Education. Bone Marrow Transplant 2019; 54;635-674. https://doi.org/10.1038/s41409-019-0565-6
  11. Marinka Mravak-Stipetic, Maria Radman, Lana Desnica, Ivan Sabol, Ranka Serventi-Seiwerth, Zinaida Perić, Nadira Durakovic, Dina Ljubas Kelecic, Ervina Bilic, Romana Ceovic, Irena Karas, Tamara Vukic, Antonela Samardzic, Ana Kerep Zelic, Mašenjka Katić, Radovan Vrhovac, Steven Zivko Pavletic, Drazen Pulanic. LOWER SERUM LEVELS OF ZINC AND MAGNESIUM ARE ASSOCIATED WITH WORSE ORAL CGVHD AND DYSGEUSIA IN CGVHD PATIENTS. 24thCongress of the European Hematology Association. EHA Library. Radman M. Jun 14, 2019; 266572; PF773
  12. Lelas A, Desnica L, Sabol I, Giljevic Z, Dusek T, Ljubas Kelecic D, Karas I, Durakovic N, Peric Z, Serventi Seiwerth R, Vrhovac R, Pavletic SZ, Pulanic D.Elevated PTH levels among chronic Graft-versus-Host Disease patients and other long term survivors after allogeneic hematopoietic stem cell transplantation. The 46th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Poster Session (P231). Bone Marrow Transplant 2021:55:356–357. https://doi.org/10.1038/s41409-020-01120-w
  13. Lelas A, Langer R, Rittenschober M, Desnica L, Greinix H, Dickinson A, Inngjerdingen M, Lawitschka A, Vrhovac R, Pulanic D, Klein S, Middeke JM, Edinger M, Wolff D. Incidence of chronic Graft-versus-Host Disease – results from a prospective multicentre analysis of 2 cohorts. The 46th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Poster Session (P206). Bone Marrow Transplant 2021:55:336–337. https://doi.org/10.1038/s41409-020-01120-w
  14. Zelić Kerep A, Kušec V, Sabol I, Desnica L, Lelas A, Babić A, Kurić L, Perić Z,  Duraković N, Serventi Seiwerth R, Batinić D, Vrhovac R, Pavletić SZ, Pulanić D. BAFF, CXCL9 and CCL15 in different clinical chronic graft versus host disease phenotypes. Zelić Kerep A, Kušec V, Sabol I, Desnica L, Lelas A, Babić A, Kurić L, Perić Z,  Duraković N, Serventi Seiwerth R, Batinić D, Vrhovac R, Pavletić SZ, Pulanić D. BAFF, CXCL9 and CCL15 in different clinical chronic graft versus host disease phenotypes. 2021 Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR

Kongresni sažeci s domaćih sastanaka:
Congress abstracts from domestic meetings:

  1. Pulanić D. Biomarkeri kronične bolesti presatka protiv primatelja. Liječ Vjesn. 2017;139(Suppl.2):54-55. – oralna prezentacija rada  na 7. Hrvatskom kongresu hematologa s međunarodnim sudjelovanjem, Solaris, Hrvatska, 22.9.2017.
  2. Barešić M, Čeović R, Vukić T, Desnica L, Vrhovac R, Pulanić D. Sličnosti i razlike sistemske skleroze i sklerotskog oblika kronične bolesti  presatka protiv primatelja. Liječ Vjesn. 2017;139(Suppl.2):58.
  3. Omerbašić M, Desnica L, Vrhovac R, Duraković N, Perić Z, Pavletić Ž, Pulanić D, Dušek T. Funkcija štitnjače u bolesnika s kroničnom reakcijom transplantata protiv primatelja nakon alogenične transplantacije krvotvornih matičnih stanica. Liječ Vjesn. 2018;140(Suppl.2):51.
  4. Brataljenović M, Pulanić D. Chronic Graft-versus-Host Disease: the importance of multidisciplinary approach. Book of Abstracts – Croatian Student Summit (CROSS). Liječ Vjesn. 2018;139(Suppl.1):49-50.
  5. Matea Hodonj, Dražen Pulanić. JAK-2 inhibitor therapy in chronic Graft versus Host Disease after allogeneic hematopoietic stem cell transplantation.  ZIMS19 Abstracts Book – Zagreb International Medical Summit, Zagreb, Croatia. Liječ Vjesn 2020;142(Supl 1):15.
  6. Zelić Kerep A, Sabol I, Desnica L, Lelas A, Antonija Babić, Lejla Kurić, Zinaida Perić, Nadira Duraković, Ranka Serventi Seiwerth, Drago Batinić, Vesna Kušec, Radovan Vrhovac, Steven Živko Pavletić, Dražen Pulanić. Pokazatelji inflamacije u različitim kliničkim fenotipskim skupinama oboljelih od kronične bolesti presatka protiv primatelja. 8. Hrvatski hematološki kongres. Liječ Vjesn 2020;142(Supl 4):74-5.
  7. Pulanić D, Desnica L, Serventi-Seiwerth R, Duraković N, Perić Z, Lelas A, Mravak Stipetić M, Petriček I, Bilić E, Čeović R, VukićT, Ljubas Kelečić D, Mazić S, Bojanić I, Zadro R, Batinić D, Bilić E, Vrhovac R, Nemet D, Pavletić SŽ. Sedam godina Multidisciplinarnog tima za kroničnu bolest presatka protiv primatelja i druge kasne komplikacije nakon transplantacije krvotvornih matičnih stanica u KBC Zagreb. 8. Hrvatski hematološki kongres. Liječ Vjesn 2020;142(Supl 4):70.
  8. Hodonj M, Pulanić D. Severe sclerotic chronic Graft-versus-Host Disease – multidisciplinary approach.  CROSS16 Abstracts Book – 16th Croatian Student Summit, Zagreb, Croatia. Liječ Vjesn 2020;142(Supl 3):74.

Diplomski radovi:
Graduate Thesis:

  1. Matija Brataljenović. Kronična bolest presatka protiv primatelja kao najznačajnija kasna komplikacija nakon alogene transplantacije matičnih krvotvornih stanica. Sveučilište u Zagrebu Medicinski fakultet, 2018. godina, mentor doc. prim. dr. sc. Dražen Pulanić, dr. med.

Doktorske disertacije:
PhD Thesis:

Obranjena doktorska disertacija:

  1. Ema Prenc, dipl. ing. biol., naziv disertacije „N-glikozilacija imunoglobulina G u kroničnoj bolesti presatka protiv primatelja nakon presadbe alogeničnih matičnih krvotvornih stanica“, mentor doc. dr. Dražen Pulanić, komentor prof. dr. Steven Živko Pavletić, uspješna obrana doktorata 5.7.2019. na Medicinskom fakultetu Sveučilišta u Zagrebu.

Obranjene teme doktorskih disertacija na javnoj raspravi:

  1. Maria Radman, dr. dent. med., naziv disertacije: “Povezanost kliničkih i laboratorijskih obilježja s oralnom kroničnom bolesti presatka protiv primatelja nakon alogenične transplantacije krvotvornih matičnih stanica”, javna rasprava teme održana u 4./2019. na Stomatološkom fakultetu Sveučilišta u Zagrebu, mentor prof. dr. Marinka Mravak Stipetić, tema prihvaćena na Sveučilištu u Zagrebu 16.10.2019.;
  2. Antonela Lelas (djevojački Samardžić), dr. med., naziv disertacije „Von Willebrandov faktor i faktor VIII u kroničnoj bolesti presatka protiv primatelja”, javna rasprava teme održana 11.11.2019. na Medicinskom fakultetu Sveučilišta u Zagrebu, mentor doc. dr. Dražen Pulanić;
  3. Ana Zelić Kerep, dr. med., naziv disertacije „Odrednice  kliničkih fenotipskih karakteristika kronične bolesti presatka protiv primatelja”, javna rasprava teme održana 27.1.2020. na Medicinskom fakultetu Sveučilišta u Zagrebu, naslov teme je izmijenjen u: „Proupalni citokini u različitim kliničkim manifestacijama kronične bolesti presatka protiv primatelja“, mentor doc. dr. Dražen Pulanić;

Predavanja na stručnim i znanstvenim sastancima:
Lectures from professional and scientific meetings:

  1. Dražen Pulanić: Novosti iz Tima za kronični GVHD KBC Zagreb (predavanje na sastanku Hrvatske kooperativne grupe za hematološke bolesti KROHEM, Vodice, 5. svibnja 2017.)
  2. Dražen Pulanić: Organizacija multidisciplinarnog tima za kronični GvHD na KBC Zagreb – primjer dobre prakse  (predavanje na 1. Simpoziju o multidisciplinarnoj suradnji u dentalnoj medicini s međunarodnim sudjelovanjem „ Zajedništvom do oralnog i općeg zdravlja – multidisciplinarna suradnja u svakodnevnom kliničkom radu“, Zagreb, 27. travanj 2018.)
  3. Dražen Pulanić: Need for multidisciplinary approach – 5 years of multidisciplinary cGVHD team in Zagreb (predavanje na 4th International Chronic GVHD Symposium and EBMT Transplant Complications Working Party Educational Course Joint Meeting, Zagreb, 9-10.11.2018.)
  4. Dražen Pulanić. Šest godina multidisciplinarnog tima za kroničnu bolest presatka protiv primatelja u KBC Zagreb. Tribina Akademije medicinskih znanosti Hrvatske (Zagreb, 25.9.2019.)
  5. Dražen Pulanić: Diagnostic criteria and response assessment in cGvHD - WG 4 activities. Expert Panel member. Integrated European Network on Chronic Graft Versus Host Disease (cGvHD) & German-Austrian-Swiss GVHD consortium joint meeting, Regensburg, Njemačka, on-line, 11. rujan 2020.
  6. Antonela Lelas: Multiorgan cGVHD with male genital involvement. Integrated European Network on Chronic Graft Versus Host Disease (cGvHD) & German-Austrian-Swiss GVHD consortium joint meeting, Regensburg, Njemačka, on-line, 11. rujan 2020.
  7. Marinka Mravak Stipetić: A more consistent team approach to addressing chronic GvHD and oral care in the cancer setting. 2020 UK Oncology Forum Virtual UKOMiC Workshop, 25. rujan 2020.
  8. Dražen Pulanić: Sedam godina multidisciplinarnog tima za kroničnu bolest presatka protiv primatelja i druge kasne komplikacije nakon alogenične transplantacije krvotvornih matičnih stanica u KBC Zagreb. 8. Hrvatski kongres hematologa, 3. listopad 2020.
  9. Dražen Pulanić: Core member of the Treatment of chronic GVHD Working group 3. NIH 2020 Chronic GVHD Consensus Project on Criteria for Clinical Trials. NIH, Bethesda, SAD, on-line, 18.-20. studeni 2020.
  10. Ervina Bilić: Core member of the Morbid forms of chronic GVHD Working group 3.  NIH 2020 Chronic GVHD Consensus Project on Criteria for Clinical Trials. NIH, Bethesda, SAD, on-line, 18.-20. studeni 2020.
  11. Dražen Pulanić: Diagnostic criteria and response assessment in cGvHD - WG 4 activities. 5th working group meeting of the COST Action EUROGRAFT (CA17138), on-line, Regensburg (Njemačka) i Oslo (Norveška), 20. siječanj 2021.

Predavanje na Poslijediplomskom studiju iz hematologije, Medicinski fakultet Sveučilišta u Zagrebu, predmet “Kronična bolest presatka protiv primatelja”:
Postgraduate Hematology Study, Medical School University of Zagreb, subject “Chronic Graft-versus-Host Disease”, lecture:

  1. Dražen Pulanić: Organizacija tima za kroničnu bolest presatka protiv primatelja (Zagreb, 21.10.2019.)